Anticancer plant-derivatives: deciphering their oncopreventive and therapeutic potential in molecular terms

Abstract Background Over the years, phytomedicines have been widely used as natural modalities for treatment and prevention of various diseases by different ethnic groups across globe. Although, 25% drugs in USA contain at least one plant-derived therapeutic compound, currently there is a paucity active medicinal ingredients pharmaceutical industry. Scientific evidence-based translation ethnomedicines their clinical application an urgent need. The anticancer associated properties (antioxidative, anti-inflammatory, pro-apoptotic epithelial-mesenchymal transition (EMT) inhibition) plant extracts phytochemicals elucidated earlier. Several derivatives are already use under prophylactic/therapeutic settings against cancer many being investigated phases trials. Main body purpose this study to systematically comprehend progress made area prophylactic potential anticancerous derivatives. Besides, we aim understand terms specific sub-phenomena, such anti-oxidative, inhibition EMT, with insight molecules/pathways them. also provides details classes compounds, source(s) molecular pathway(s) targeted In addition antioxidative antiproliferative potentials derivatives, emphasizes on EMT-inhibition other ‘anticancer related’ properties. EMT highlighted phenomenon choice targeting due its role induction metastasis drug resistance. Different pre-clinical or trials, promising chemopreventive/anticancer activities enlisted compounds showing synergistic activity combination existing discussed. review unravels need carrying out pan-signalome studies identifying cardinal pathways modulated phytomedicine(s), cases, has/have randomly studied. Conclusion This compiles regarding impact cancers oncogenic processes, tested diverse experimental model systems. Availability more comprehensive information phyto-constituents, relative abundance crude drugs, pathways/molecules phytomedicines, long-term toxicity data safe combinatorial settings, would open greater avenues utilization future dreaded disease. Graphical